Stem Cell Reports Report Frizzled7 Functions as aWnt Receptor in Intestinal Epithelial Lgr5 StemCells

Dustin J. Flanagan,1,2,10 Toby J. Phesse,3,10,11 Nick Barker,4,5,10 Renate H.M. Schwab,1,2 Nancy Amin,1,2 JordaneMalaterre,6 Daniel E. Stange,7 Cameron J. Nowell,3 Scott A. Currie,1,2 Jarel T.S. Saw,1,2 Eva Beuchert,1,2 Robert G. Ramsay,6 Owen J. Sansom,8 Matthias Ernst,3,11 Hans Clevers,7 and Elizabeth Vincan1,2,9,* 1Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, VIC 3010, Australia 2Victorian Infectious Diseases Reference Laboratory, Melbourne, VIC 3000, Australia 3Walter and Eliza Hall Institute and Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia 4Institute of Medical Biology, Singapore 138648, Singapore 5MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9YL, UK 6Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3010, Australia 7Hubrecht Institute for Developmental Biology and Stem Cell Research, 3584CT Utrecht, the Netherlands 8Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK 9Curtin University, Perth, WA 6845, Australia 10Co-first author 11Present address: Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia *Correspondence: [email protected] http://dx.doi.org/10.1016/j.stemcr.2015.03.003 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).